Our closed form structure was maintained by an unidentified molecule in the active site, which might mimic its substrate. Structural comparison analysis revealed that IRG1 can exist in either an open or closed conformation and that this is controlled by the A1 loop located proximal to the active site. In this study, we solved the structure of IRG1 from Mus musculus (mouse IRG1). The production of itaconate in biological systems is catalyzed by cis-aconitate decarboxylase (CAD, also known as immune responsive gene 1 (IRG1) in mammals). Itaconate, produced as an offshoot of the TCA cycle, is a multifunctional immunometabolite possessing antibacterial, antiviral, immune regulation, and tumor progression activities. Keep in suitable, closed containers for disposal.ĭOWNLOAD The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation Chun, Hye Lin,Lee, So Yeon,Kim, Ki-Hwa,Lee, Chang Sup,Oh, Tae-Jin,Ho Park, Hyun, (7) Discharge into the environment must be avoided. Prevent further leakage or spillage if safe to do so. Wear self-contained breathing apparatus for firefighting if necessary. Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. If swallowed Never give anything by mouth to an unconscious person. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
ITANCONIC ACID INMR SKIN
In case of skin contact Wash off with soap and plenty of water. If not breathing, give artificial respiration. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. P310 Immediately call a POISON CENTER/doctor/… Remove contact lenses, if present and easy to do. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. P280 Wear protective gloves/protective clothing/eye protection/face protection. Itaconic acid Safety information and MSDS